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As a dietary supplement, N-acetyl-L-cysteine supports comprehensive health in a variety of ways, including promoting normal liver function. NAC is a powerful antioxidant that protects cells from oxidative stress.




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N-acetyl-L-cysteine is an easily-absorbed nutrient with potent benefits for whole body health.1 N-acetyl-L-cysteine also helps replenish your body's supply of glutathione. N-acetyl-L-cysteine and glutathione have powerful antioxidant effects.2-5


N-acetyl-L-cysteine is a powerful nutrient that can support vital functions such as respiration (breathing function), liver, and immune function. It also provides antioxidant support and helps scavenge the body for free radicals and other compounds which are not native to the human body.


Glutathione is a powerful antioxidant which helps protects cells from damage from free radicals. Furthermore, research has also revealed that besides playing a role against toxins, N-acetylcysteine promotes immune system health [5].


It also defends against attacks from foreign compounds at the cellular level and helps protects vulnerable neurons from oxidative stress. Because of its quick absorption rate, N-acetyl-L-cysteine is a potent nutrient in its own right.


N-acetylcysteine is derived from the simple amino acid cysteine which can offer significant protection against a broad number of toxins [5]. These include acrolein (found in cigarette smoke and auto exhaust), paraquat (a toxic herbicide). N-acetylcysteine may play a role in protecting lung tissue against common challenges through its antioxidant activity [5].


Boosted glutathione levels have shown particularly positive effects on those people with weak immune systems [5]. And more than 30 placebo-controlled studies on cellular glutathione have shown that N-acetyl-L-cysteine can favourably affect energy production, well-being, and quality of life [5].


N-acetylcysteine (NAC) is the non-essential amino acid cysteine with an acetyl group. The body uses L-cysteine for the production of the amino acids serine and methionine and the tripeptide glutathione. N-Acetyl-L-Cysteine is rapidly absorbed into the body. Life Extension provides GMO-free NAC.


Please note: People taking an N-acetylcysteine supplement should drink 6-8 glasses of water a day to prevent cysteine kidney stones. Cysteine kidney stones are rare, but do occur.


L-cysteine is a conditionally essential, proteinogenic amino acid and precursor of the important bodily antioxidant glutathione as well as taurine. This amino acid also plays a role in numerous metabolic processes including in the immune system.


Now, can it do it for all people? Absolutely not, because to make glutathione needs more than just N-Acetyl Cysteine. Yes, NAC is a primary ingredient. But N-Acetyl Cysteine or cysteine is not the only ingredient needed to make glutathione.


I am going to write the word cysteine down on a piece of paper and draw an arrow. Where does it go? Well, it goes to a gene called GCLC. The GCLC gene helps make another compound, which is still not glutathione.


Now, let's say you do not have that genetic variation, let's say you have all the mitochondrial health and all the energy you want. You have all the cysteine you want because you're taking NAC, and you have all the glutamates you want.


Now you need to know what slows the GCLC gene down from functioning. There are two major things that prevent your body from making gamma-glutamyl-cysteine, which is the next step in making glutathione.


There are all sorts of things reducing your body's ability to make glutathione from just supplementing with N-Acetyl Cysteine. My point with this education is to inform you that N-Acetyl Cysteine, yes, it can raise glutathione levels if everything else is working. But if it's not working, then all you're doing is increasing your cysteine levels, which could be helpful because cysteine goes on and does other things.


Lizzo G, Migliavacca E, Lamers D, et al. A randomized controlled clinical trial in healthy older adults to determine efficacy of glycine and n-acetylcysteine supplementation on glutathione redox status and oxidative damage. Front Aging. 2022;3:852569. doi:10.3389/fragi.2022.852569


Assimakopoulos SF, Aretha D, Komninos D, et al. N-acetyl-cysteine reduces the risk for mechanical ventilation and mortality in patients with COVID-19 pneumonia: a two-center retrospective cohort study. Infect Dis. 2021;53(11):847-854. doi:10.1080/23744235.2021.1945675


Hildebrandt W, Sauer R, Bonaterra G, Dugi KA, Edler L, Kinscherf R. Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status. Am J Clin Nutr. 2015;102(5):1014-1024. doi:10.3945/ajcn.114.101964


Barekat F, Tavalaee M, Deemeh MR, et al. A preliminary study: N-acetyl-L-cysteine improves semen quality following varicocelectomy. Int J Fertil Steril. 2016;10(1):120-126. doi:10.22074/ijfs.2016.4777


Masnadi Shirazi K, Sotoudeh S, Masnadi Shirazi A, Moaddab SY, Nourpanah Z, Nikniaz Z. Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial. Clin Res Hepatol Gastroenterol. 2021;45(4):101532. doi:10.1016/j.clinre.2020.08.010


Fowdar K, Chen H, He Z, et al. The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review. Heart Lung. 2017;46(2):120-128. doi:10.1016/j.hrtlng.2016.12.004


Nikbakht M, Ahmadi F, Vaseghi G, et al. The role of n-acetylcysteine in platelet aggregation and reperfusion injury in recent years. Curr Clin Pharmacol. 2017;12(2):83-91. doi:10.2174/1574884712666170704145842


Antioxidant activity. With regard to antioxidant activity, the cysteine component of NAC combines with glutamate and glycine, all of which are precursors in the production of glutathione.8 In the production of glutathione, cysteine is the rate-limiting step.5 Glutathione, in turn, is a major endogenous antioxidant.3 In fact, it is the most generic cellular antioxidant in the body.8 Because of its antioxidant activity, glutathione is essential for the immune system to exert its full potential. While glutathione is commercially available, its oral bioavailability remains controversial.9 Therefore, its precursor, NAC, has been a more promising avenue to pursue in clinical investigations.9


NAC is both an antioxidant and amino acid (building blocks of protein). Specifially, NAC is a derivative of the amino acid L-cysteine, an essential precursor used by the body to produce glutathione. Glutathione is an extremely important and powerful antioxidant produced by the body to help protect against free radical damage, and is a critical factor in supporting a healthy immune system.


Javanmanesh F, Kashanian M, Rahimi M, Sheikhansari N.A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome. Gynecol Endocrinol. 2015 Dec 10:1-5.


Maged AM, Elsawah H, Abdelhafez A, Bakry A, Mostafa WA.The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. Gynecol Endocrinol. 2015;31(8):635-8.


Thakker D, Raval A, Patel I, Walia R. N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials. Obstet Gynecol Int. 2015;2015:817849.


Cheraghi E, Mehranjani MS, Shariatzadeh MA, Esfahani MH, Ebrahimi Z.N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin. Reprod Fertil Dev. 2014 Nov 13.


Abu Hashim H, Anwar K, El-Fatah RA. N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial. J Womens Health (Larchmt). 2010 Nov;19(11):2043-8. Epub 2010 Oct 12.


The body needs 20 amino acids to maintain normal function. Of those, the body can make 11 by itself, which means a person does not need to eat in order to get them. L-cysteine is one of these amino acids.


In the body, NAC converts to l-cysteine, a nonessential amino acid. The body then uses l-cysteine to make glutathione, which is a tripeptide or chain of amino acids composed of cysteine, glycine, and glutamic acid.


Scientists believe that the supply of l-cysteine in the cell limits the rate of glutathione production in the body. So, increasing l-cysteine supply can increase this rate. NAC may be less toxic and more soluble than l-cysteine itself, which is why NAC is often used in supplements instead of l-cysteine by itself.


NAC (N-Acetyl Cysteine) is a form of the amino acid l-cysteine and acts as a powerful free radical scavenger.* It is a precursor to and supports tissue levels of glutathione (GSH), the principle defense within the body against reactive oxygen species (ROS).* NAC has also been shown to support healthy lung function through its mucolytic capability.*


NuMedica NAC (N-Acetyl Cysteine) is a type of amino acid called l-cysteine. This supplement works as a very powerful free radical. Free radicals like this work in the body to remove toxins and other components within the body that can lead to illness and disease. NuMedica NAC works as a preventative tool and supports tissue levels of glutathione (known as GSH) as a way of defending the body from reactive oxygen species (known as ROS). It also works to protect the body from detoxification from drugs, compounds of all types including metabolites. NuMedica NAC can specifically help to support healthy lung function. NuMedica NAC provides 600 mg tablets of this high quality nutrient necessary for overall body health and detoxification.


N-acetyl L-cysteine (also known as NAC and acetylcysteine) is the acetylated form of L-cysteine. L-Cysteine is a semi-essential, sulfur-containing amino acid that is an important structural component in many proteins. 041b061a72


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